In the 12 treated patients, Li T(1/2) during SPS was on average 48.9% shorter than without SPS. Median Li T(1/2) in the treated and control groups was 20.5 and 43.2 hours, respectively (p = 0.0006). For this study, at least three serum Li levels were required for T(1/2) calculations.įorty-eight patients met inclusion requirements, 12 of whom had taken SPS. A group comparison and a within-patient comparison were performed to compare the effect of SPS on the median Li half-life (T(1/2)). All cases of chronic Li intoxication were reviewed in two adult-care hospitals from 2000 to 2009. Sodium polystyrene sulfonate (SPS, Kayexalate), a cation exchanger, has been promising in animal models and human reports to reduce absorption and enhance elimination of Li.Ī retrospective cohort study was conducted.
Treatment of Li toxicity includes supportive measures and hemodialysis in severe cases, but this modality is not always immediately available.
Lithium (Li) is a first-line treatment for bipolar disorder but has a narrow therapeutic index.
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